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Incredible! Scientist’s Breakthrough Discovery Could END Heart Disease #science #medicine #heart

Virtually everyone knows someone with heart disease of some sort. Now, thanks to modern medical scientific breakthroughs, heart disease may be a thing of the past, literally outpatient surgery and cured.

This is not fake news, this is real medical science. Continue reading and be amazed.

First, some facts on Cardiovascular diseases (CVDs)

CVDs are the number 1 cause of death globally: more people die annually from CVDs than from any other cause.

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An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Of these deaths, an estimated 7.4 million were due to coronary heart disease and 6.7 million were due to stroke.

Over three quarters of CVD deaths take place in low- and middle-income countries.

Out of the 17 million premature deaths (under the age of 70) due to noncommunicable diseases in 2015, 82% are in low- and middle-income countries, and 37% are caused by CVDs.

Most cardiovascular diseases can be prevented by addressing behavioral risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol using population-wide strategies.

People with cardiovascular disease or who are at high cardiovascular risk (due to the presence of one or more risk factors such as hypertension, diabetes, hyperlipidaemia or already established disease) need early detection and management using counseling and medicines, as appropriate.

Now, to the amazing part…

Early one Saturday morning in March 2015, Boston Children’s hospital got a call from a hospital in Maine.

Doctors there wanted to transfer to Boston Children’s a newborn baby boy whose heart had been deprived of oxygen during surgery to fix a congenital defect with an experimental treatment created by Dr. Sitaram Emani and Dr James McCully of New England Deaconess Hospital.

The baby was on an ECMO but his heart had not recovered.

“We turned the intensive care unit into an operating room,” Emani said.

He snipped a tiny piece of muscle from the baby’s abdomen. McCully grabbed it and raced down the hall.

In his previous research working with pigs, McCully took a plug of abdominal muscle the size of a pencil eraser, whirled it in a blender to break the cells apart, added some enzymes to dissolve cell proteins, and spun the mix in a centrifuge to isolate the mitochondria.

He recovered between 10 billion and 30 billion mitochondria, and injected 1 billion directly into the injured heart cells.

To his surprise, the mitochondria moved like magnets to the proper places in the cells and began supplying energy. The pig hearts recovered.

Now, with a real, live baby’s life on the line, he was back into surgery with a test tube of the precious mitochondria. Emani used an echocardiogram to determine where to inject them for the experimental treatment.

“The spot that is weakest is where we want to go,” he said. “It is important to give as much of a boost as you can.”

He injected 1 billion mitochondria, in about a quarter of a teaspoon of fluid.

Within two days, the baby had a normal heart, strong and beating quickly. “It was amazing,” Emani said.

The scientists have now treated 11 babies with mitochondria, and all but one were able to come off ECMO, Emani said. Still, three of them ultimately died, which Emani attributes to a delay in treatment and other causes.

Two died because their hearts were still so damaged, and one died of an infection. All of the more recent patients survived and are doing well.

In comparison, the death rate among a similar group of babies that did not get mitochondrial transplants was 65 percent. And none of the untreated babies recovered any of their heart function — more than a third of the survivors ended up on heart transplant lists.

In comparison, the death rate among a similar group of babies that did not get mitochondrial transplants was 65 percent. And none of the untreated babies recovered any of their heart function — more than a third of the survivors ended up on heart transplant lists.

More recently, Emani and his colleagues have discovered that they can infuse mitochondria into a blood vessel feeding the heart, instead of directly into the damaged muscle. Somehow the organelles will gravitate almost magically to the injured cells that need them and take up residence. 2

He and his colleagues are persuaded that these transplants work, but acknowledge that it would take a randomized trial to prove it.

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But what about adult heart patients?

Researchers are hoping that mitochondrial transplants also can repair heart muscle damaged during heart attacks in adults. And finding enough of those patients should not be an issue, said Dr. Peter Smith, chief of cardiothoracic surgery at Duke University.

Already researchers are planning such a trial. The plan is to infuse mitochondria or a placebo solution into the coronary arteries of people having bypass surgery or — an even more dire situation for the heart — having both bypass and valve surgery.

The patients would be those whose hearts are so damaged that it would be difficult to wean them from heart-lung machines after surgery. For these desperate patients, mitochondrial transplants “are a really intriguing option,” Smith said. 3

“The likelihood is very high” that the study will begin next year, said Annetine Gelijns, a biostatistician at Mount Sinai Medical Center in New York.

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Mr Americana, Overpasses News Desk
July 10th, 2018

 

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